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Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease

Powerful antioxidant protection against oxidative stress

These are not only damaging, but they can also single-handedly deplete glutathione, creating an imbalance between Phase 1 and Phase 2 (see below) activity.7 Toxic reactions can occur due to the buildup of reactive intermediate forms resulting from phase 1 detoxification, so further work needs to be done to process and eliminate toxins

(2015) Five Chinese patients with 5-oxoprolinuria due to glutathione synthetase and 5-oxoprolinase deficiencies, Brain Dev

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GSH also exerts its cytoprotective function through conjugation reactions which mediates detoxification of xenobiotics and their metabolites